| + |
Microtubule_polimerization | up-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266830 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28347630 |
Microtubules are essential for the generation, migration and differentiation of neurons. Within dendrites microtubules have also been implicated in the formation and plasticity of spines. For instance, the treatment of hippocampal neurons with low doses of the microtubule destabilizing drug Nocodazole impairs BDNF induced dendritic spine formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYTH2 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264909 |
|
|
Rattus norvegicus |
Pyramidal Neuron |
| pmid |
sentence |
| 14565977 |
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RAB6B | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266874 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 25492866 |
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. COH1 and RAB6 regulate neurite outgrowth in primary neurons |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
GPRIN1 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265799 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 22956546 |
GAP-43 and G protein regulated inducer of neurite outgrowth 1 (Gprin1) in differentiating cells. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Rett syndrome |
| + |
RUSC1 | up-regulates
binding
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272776 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15024033 |
Overexpression studies in PC12 cells indicate that Nesca facilitates neurotrophin-dependent neurite outgrowth at nonsaturating doses of nerve growth factor (NGF). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPAST | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269045 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 15716377 |
Using purified components, we also show that Spastin interacts directly with microtubules and is sufficient for severing. These studies suggest that defects in microtubule severing are a cause of axonal degeneration in human disease. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
AUTS2 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266818 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25533347 |
AUTS2 is involved in neurite outgrowth and branch formation in neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BAIAP2 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265555 |
|
|
Mus musculus |
N1E-115 Cell |
| pmid |
sentence |
| 19171758 |
Ectopic expression of IRSp53 in mouse neuroblastoma N1E115 cells induces neurite outgrowth . Kank inhibits IRSp53-mediated neurite outgrowth in N1E115 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LRFN4 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264097 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
This study finds that all SALMs (SALMs 1–5) possess the abilityto promote neurite outgrowth and branching, as demonstrated byoverexpression and knockdown experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNuRF | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14609955 |
Human NURF (hNURF) is enriched in brain, and we demonstrate that it regulates human Engrailed, a homeodomain protein that regulates neuronal development in the mid-hindbrain. Furthermore, we show that hNURF potentiates neurite outgrowth in cell culture. Taken together, our data suggess a role for an ISWI complex in neuronal growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
LRFN1 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264100 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
This study finds that all SALMs (SALMs 1–5) possess the abilityto promote neurite outgrowth and branching, as demonstrated byoverexpression and knockdown experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLITRK1 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19640509 |
Phosphorylation of SLITRK1 on the CK2 phosphorylation site modulated SLITRK1-enhanced neurite outgrowth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRFN3 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264101 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
This study finds that all SALMs (SALMs 1–5) possess the abilityto promote neurite outgrowth and branching, as demonstrated byoverexpression and knockdown experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCDH11X | down-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265163 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25687328 |
Our previous research found that protocadherin 11 X-linked protein (Pcdh11x) is predominantly expressed in neurons and has an influence on dendritic branching. In this study, gain-of-function and loss-of-function experiments revealed that Pcdh11x acts as a negative regulator of dendritic branching in cultured cortical neurons derived from embryonic day 16 mice. Overexpression of wild-type Pcdh11x (Pcdh11x-GFP) reduced dendritic complexity, whereas knockdown of Pcdh11x increased dendritic branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| + |
VASP | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18508258 |
Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RETREG3 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261490 |
|
|
Homo sapiens |
IMR-32 Cell |
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRK1 | down-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261491 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EVL | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18508258 |
Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DSCAML1 | down-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264275 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30745319 |
Nuclear DSCAM and DSCAML1 impair neurite outgrowth. this demonstrates that enhanced nuclear translocation of the DSCAM and DSCAML1 ICDs profoundly impairs neurite outgrowth and development of primary cortical neurons |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB6C | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266875 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 25492866 |
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. COH1 and RAB6 regulate neurite outgrowth in primary neurons |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ANKRD11 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266733 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29274743 |
We showed that ANKRD11 regulates dendrite outgrowth, arborization, and spine formation via Trkb transcription and activation of its downstream effectors in the developing mouse brain. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
VPS13B | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266872 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 25492866 |
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. COH1 and RAB6 regulate neurite outgrowth in primary neurons |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ENAH | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268392 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18508258 |
Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARF6 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264908 |
|
|
Rattus norvegicus |
Pyramidal Neuron |
| pmid |
sentence |
| 14565977 |
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
GAMT | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265795 |
|
|
in vitro |
|
| pmid |
sentence |
| 26319512 |
GAMT enzyme (EC#2.1.1.2) deficiency caused by mutations in the GAMT gene (MIM# 601240) results in the depletion of creatine and accumulation of guanidinoacetate (GAA). Creatine has a buffering and transport function of high-energy phosphates in brain and muscle and is essential for growth cone migration, dendritic and axonal elongation, neurotransmitter release, and co-transmission on gamma amino butyric acid (GABA) postsynaptic receptors in the central nervous system |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Rett syndrome |
| + |
GAP43 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266769 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21938722 |
Growth associated protein 43 (Gap43) is a neuron-specific phosphoprotein, which plays critical role in axon growth and synapses functions during neurogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DPYSL2 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264842 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25040932 |
In the non-phosphorylated state, CRMP2 binding to tubulin induces the promotion of tubulin polymerisation leading to dendrite outgrowth while |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEXMIF | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269659 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 27822498 |
The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and δ-Catenin Signaling. We found that KIDLIA is distributed exclusively in the nucleus |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
DSCAM | down-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264276 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30745319 |
Nuclear DSCAM and DSCAML1 impair neurite outgrowth. this demonstrates that enhanced nuclear translocation of the DSCAM and DSCAML1 ICDs profoundly impairs neurite outgrowth and development of primary cortical neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB6A | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266873 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 25492866 |
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. COH1 and RAB6 regulate neurite outgrowth in primary neurons |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
LRFN2 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264099 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
This study finds that all SALMs (SALMs 1–5) possess the abilityto promote neurite outgrowth and branching, as demonstrated byoverexpression and knockdown experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRFN5 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264098 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
This study finds that all SALMs (SALMs 1–5) possess the abilityto promote neurite outgrowth and branching, as demonstrated byoverexpression and knockdown experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Neurite_outgrowth