Summary

Name TRAF7
Full Name E3 ubiquitin-protein ligase TRAF7
Synonyms RING finger and WD repeat-containing protein 1, RING finger protein 119, TNF receptor-associated factor 7 | RFWD1, RNF119
Primary ID Q6Q0C0
Links - -
Type protein
Relations 4
Function E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Induces apoptosis when overexpressed (PubMed:15001576). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.

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Relations

Regulator Mechanism target score ℹ
+ TRAF7up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRAF7 0.2
Publications: 1 Organism: Homo Sapiens
+ TRAF7up-regulates img/indirect-activation.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ TRAF7up-regulates img/direct-activation.png binding MAP3K3 0.484
Publications: 1 Organism: Homo Sapiens