Summary

Name SMARCD3
Full Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
Synonyms 60 kDa BRG-1/Brm-associated factor subunit C, BRG1-associated factor 60C, BAF60C | BAF60C
Primary ID Q6STE5
Links - -
Type protein
Relations 10
Pathways P38 Signaling and Myogenesis
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding Neural progenitor-specific SWI/SNF 0.762
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMARCD3 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ form complex img/form-complex.png binding Muscle cell-specific SWI/SNF SMARCA4 variant 0.739
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.56
Publications: 1 Organism: In Vitro
Pathways:P38 Signaling and Myogenesis
+ form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1B variant 0.749
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.364
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ form complex img/form-complex.png binding SWI/SNF ACTL6A-ARID1A-SMARCA2 variant 0.745
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMARCD3 0.377
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1A variant 0.749
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ form complex img/form-complex.png binding SMARCD3 0.2
Publications: 1 Organism: Homo Sapiens