Relation Results

Summary

Name BCOR
Full Name BCL-6 corepressor
Synonyms BCoR | KIAA1575
Primary ID Q6W2J9
Links - -
Type protein
Relations 12
Pathways Acute Myeloid Leukemia, MLL fusion protein in AML
Function Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins suc ...
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Type: Score: Layout: SPV 
0.5470.5490.20.70.20.5480.3130.8860.20.3790.70.251BCORHDAC5Noncanonical PRC1HOXA5ProliferationMLL-AF9RNF2HDAC3BCL6HOXA7HDAC1DifferentiationHOXA9

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Relations
Regulator
Mechanism
target
score ℹ
+ BCORup-regulates activity img/direct-activation.png binding HDAC5 0.547
Identifier Residue Sequence Organism Cell Line
SIGNOR-252238 Homo sapiens HEK-293 Cell
pmid sentence
BCoR can interact w Because HDACs appear to be involved in repression by an increasing number of transcriptional repressors, we tested whether BCoR can associate with HDACs. BCoR can interact with HDAC1, HDAC3, and HDAC-B/5 more strongly than with HDAC-A/4, HDAC-C, HDAC-D, and HDAC-E.
Publications: 1 Organism: Homo Sapiens
+ BCORform complex img/form-complex.png binding Noncanonical PRC1 0.549
Identifier Residue Sequence Organism Cell Line
SIGNOR-255276 Mus musculus
pmid sentence
inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR.
Publications: 1 Organism: Mus Musculus
+ BCORdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HOXA5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256012 Mus musculus
pmid sentence
Importantly, our results showed that BCOR is a repressor of HoxA cluster of genes (HoxA5, HoxA7 and HoxA9) in myeloid cells. Knock-down of HoxA5, HoxA7 and HoxA9 significantly decreased the clonogenic growth of Bcor mutant and wild type cells, demonstrating the Hox genes, as targets of BCOR, played an important role in mediating BCOR’s function in regulating myeloid cell proliferation.
Publications: 1 Organism: Mus Musculus
+ BCORdown-regulates img/indirect_inhibition.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256011 Mus musculus Bone Marrow Cell
pmid sentence
Our results strongly suggest that BCOR plays an indispensable role in hematopoiesis by inhibiting myeloid cell proliferation and differentiation and offer a mechanistic explanation for how BCOR regulates gene expression such as Hox genes.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ MLL-AF9up-regulates activity img/direct-activation.png binding BCOR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256142 Mus musculus NIH-3T3 Cell
pmid sentence
As BCoR binds the C-terminus of AF9, it seems likely that BCoR will also bind chimeric MLL–AF9 proteins. As transcriptional repressors, BCoR or Pc3 bound to MLL–AF9 might interfere with the expression of genes required for normal hematopoiesis.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ BCORup-regulates activity img/direct-activation.png binding RNF2 0.548
Identifier Residue Sequence Organism Cell Line
SIGNOR-252241 Homo sapiens
pmid sentence
BcoR and Fbxl10/Jhdm1B are among the most abundant Ring1B/Rnf2 interactors identified with the highest confidence, and their association has been validated by coimmunoprecipitation studies; hence we call this the Fbxl10-BcoR complex. In summary, we have widened the set of multiprotein complexes containing the Polycomb group protein Ring1B/Rnf2. The new interactors contain protein motifs whose enzymatic activities and binding properties would expand the regulatory potential and gene target diversity of Ring1B/Rnf2 complexes in terms of recruitment to and modification of chromatin
Publications: 1 Organism: Homo Sapiens
+ BCORup-regulates activity img/direct-activation.png binding HDAC3 0.313
Identifier Residue Sequence Organism Cell Line
SIGNOR-252237 Homo sapiens
pmid sentence
BCoR can interact w Because HDACs appear to be involved in repression by an increasing number of transcriptional repressors, we tested whether BCoR can associate with HDACs. BCoR can interact with HDAC1, HDAC3, and HDAC-B/5 more strongly than with HDAC-A/4, HDAC-C, HDAC-D, and HDAC-E.
Publications: 1 Organism: Homo Sapiens
+ BCORup-regulates activity img/direct-activation.png binding BCL6 0.886
Identifier Residue Sequence Organism Cell Line
SIGNOR-252235 Homo sapiens HEK-293 Cell
pmid sentence
In this study we have shown that BCoR interacts with BCL-6 and potentiates transcriptional repression by BCL-6 with striking specificity.
Publications: 1 Organism: Homo Sapiens
+ BCORdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HOXA7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256013 Mus musculus
pmid sentence
Importantly, our results showed that BCOR is a repressor of HoxA cluster of genes (HoxA5, HoxA7 and HoxA9) in myeloid cells. Knock-down of HoxA5, HoxA7 and HoxA9 significantly decreased the clonogenic growth of Bcor mutant and wild type cells, demonstrating the Hox genes, as targets of BCOR, played an important role in mediating BCOR’s function in regulating myeloid cell proliferation.
Publications: 1 Organism: Mus Musculus
+ BCORup-regulates activity img/direct-activation.png binding HDAC1 0.379
Identifier Residue Sequence Organism Cell Line
SIGNOR-252236 Homo sapiens HEK-293 Cell
pmid sentence
BCoR can interact w Because HDACs appear to be involved in repression by an increasing number of transcriptional repressors, we tested whether BCoR can associate with HDACs. BCoR can interact with HDAC1, HDAC3, and HDAC-B/5 more strongly than with HDAC-A/4, HDAC-C, HDAC-D, and HDAC-E.
Publications: 1 Organism: Homo Sapiens
+ BCORdown-regulates img/indirect_inhibition.png Differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256010 Mus musculus Bone Marrow Cell
pmid sentence
Our results strongly suggest that BCOR plays an indispensable role in hematopoiesis by inhibiting myeloid cell proliferation and differentiation and offer a mechanistic explanation for how BCOR regulates gene expression such as Hox genes.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ BCORdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HOXA9 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-256014 Mus musculus
pmid sentence
Importantly, our results showed that BCOR is a repressor of HoxA cluster of genes (HoxA5, HoxA7 and HoxA9) in myeloid cells. Knock-down of HoxA5, HoxA7 and HoxA9 significantly decreased the clonogenic growth of Bcor mutant and wild type cells, demonstrating the Hox genes, as targets of BCOR, played an important role in mediating BCOR’s function in regulating myeloid cell proliferation.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
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