3.0
Summary
| Name |  ATG14View Modifications |
| Full Name | Beclin 1-associated autophagy-related key regulator |
| Synonyms | Barkor, Autophagy-related protein 14-like protein, Atg14L | ATG14L, KIAA0831 |
| Primary ID | Q6ZNE5 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Autophagy |
| Function | Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ULK1 | up-regulates activity 
phosphorylation
|
ATG14 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATG14 | up-regulates activity
binding
|
PIK3C3 | 0.879 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Autophagy | |||
| + | ATG14 | form complex 
binding
|
Vps34 Complex I | 0.909 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Autophagy | |||