| + |
MCM10 | down-regulates 
binding
|
RECQL4 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187701 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19696745 |
Mcm10 inhibits recq4 helicase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCM10 | up-regulates quantity by stabilization 
relocalization
|
POLA1 |
0.857 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261271 |
|
|
in vitro |
|
| pmid |
sentence |
| 19608746 |
Mcm10 is an essential eukaryotic protein required for the initiation and elongation phases of chromosomal replication. Specifically, Mcm10 is required for the association of several replication proteins, including DNA polymerase alpha (pol alpha), with chromatin. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Cullin4-RBX1-DDB1 | down-regulates quantity by destabilization
polyubiquitination
|
MCM10 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272045 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22570418 |
By screening the known DDB1 interacting proteins, we discovered that VprBP is the substrate recognition subunit that targets Mcm10 for degradation. Hence, these results establish that Cul4-DDB1-VprBP ubiquitin ligase mediates the stress-induced proteolysis of replication factor, Mcm10. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DCAF1 | down-regulates quantity by destabilization
binding
|
MCM10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272046 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22570418 |
By screening the known DDB1 interacting proteins, we discovered that VprBP is the substrate recognition subunit that targets Mcm10 for degradation. Hence, these results establish that Cul4-DDB1-VprBP ubiquitin ligase mediates the stress-induced proteolysis of replication factor, Mcm10. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MCM10
- 
- 