3.0
Summary
| Name |  SPRED1View Modifications |
| Full Name | Sprouty-related, EVH1 domain-containing protein 1 |
| Synonyms | Spred-1, hSpred1 | |
| Primary ID | Q7Z699 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
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