Summary

Name SNX32
Full Name Sorting nexin-32
Synonyms Sorting nexin-6B | SNX6B
Primary ID Q86XE0
Links - -
Type protein
Relations 2
Function Involved in endosomal trafficking of cargo proteins, including transferrin-bound transferrin receptor (TFRC), cation-independent mannose-6-phosphate receptor (IGF2R) and epidermal growth factor receptor (EGFR) (PubMed:37158588, PubMed:39073202). Functions redundantly with other BAR domain-containing sorting nexins in endosome to trans-Golgi network transport of IGF2R (PubMed:39073202). Regulates in coordination with SNX5 sorting and trafficking of EGF-activated EGFR to multivesicular bodies for lysosomal degradation (PubMed:39073202). Plays an essential role in neurite outgrowth, controlling basigin/EMMPRIN (BSG) trafficking to the cell surface (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ SNX32form complex img/form-complex.png binding SNX1-SNX32 sorting nexin complex 0.475
Publications: 1 Organism: Homo Sapiens
+ SNX32form complex img/form-complex.png binding SNX2-SNX32 sorting nexin complex 0.469
Publications: 1 Organism: Homo Sapiens