| + |
CSNK2A1 | down-regulates activity 
phosphorylation
|
FUNDC1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273622 |
Ser13 |
PPPQDYEsDDDSYEV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24746696 |
Here, we identify that the mitochondrially localized PGAM5 phosphatase interacts with and dephosphorylates FUNDC1 at serine 13 (Ser-13) upon hypoxia or carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) treatment. Dephosphorylation of FUNDC1 catalyzed by PGAM5 enhances its interaction with LC3, which is abrogated following knockdown of PGAM5 or the introduction of a cell-permeable unphosphorylated peptide encompassing the Ser-13 and LIR of FUNDC1. We further observed that CK2 phosphorylates FUNDC1 to reverse the effect of PGAM5 in mitophagy activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ULK1 | up-regulates activity 
phosphorylation
|
FUNDC1 |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273606 |
Ser17 |
DYESDDDsYEVLDLT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24671035 |
Here, we show that ULK1 is upregulated and translocates to fragmented mitochondria upon mitophagy induction by either hypoxia or mitochondrial uncouplers. At mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to LC3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PGAM5 | up-regulates activity
dephosphorylation
|
FUNDC1 |
0.619 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273654 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24746696 |
Here, we identify that the mitochondrially localized PGAM5 phosphatase interacts with and dephosphorylates FUNDC1 at serine 13 (Ser-13) upon hypoxia or carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) treatment. Dephosphorylation of FUNDC1 catalyzed by PGAM5 enhances its interaction with LC3, which is abrogated following knockdown of PGAM5 or the introduction of a cell-permeable unphosphorylated peptide encompassing the Ser-13 and LIR of FUNDC1. We further observed that CK2 phosphorylates FUNDC1 to reverse the effect of PGAM5 in mitophagy activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FUNDC1
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