3.0
Summary
| Name |  MFN1View Modifications |
| Full Name | Mitofusin-1 |
| Synonyms | Fzo homolog, Transmembrane GTPase MFN1 | |
| Primary ID | Q8IWA4 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Pathways | Mitochondrial dynamics in T cell exhaustion |
| Function | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCB | down-regulates activity 
phosphorylation
|
MFN1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ERK1/2 | up-regulates activity 
phosphorylation
|
MFN1 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | MARCHF5 | down-regulates quantity by destabilization
ubiquitination
|
MFN1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PINK1 | down-regulates quantity 
ubiquitination
|
MFN1 | 0.688 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKN | down-regulates quantity
ubiquitination
|
MFN1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AMFR | down-regulates quantity by destabilization
polyubiquitination
|
MFN1 | 0.318 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | MFN1 | up-regulates 
|
Mitochondrial_fusion | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |