Summary

Name DOCK3
Full Name Dedicator of cytokinesis protein 3
Synonyms Modifier of cell adhesion, Presenilin-binding protein, PBP | KIAA0299, MOCA
Primary ID Q8IZD9
Links - -
Type protein
Relations 1
Function Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ DOCK3up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.642
Publications: 1 Organism: Homo Sapiens