| + |
ATM | up-regulates activity 
phosphorylation
|
CCAR2 |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267661 |
Thr454 |
AAEAAPPtQEAQGET |
Homo sapiens |
|
| pmid |
sentence |
| 22735644 |
Here, we report that, in human cell lines, DNA damage triggered the phosphorylation of DBC1 on Thr454 by ATM (ataxia telangiectasia-mutated) and ATR (ataxia telangiectasia and Rad3-related) kinases. Phosphorylated DBC1 bound to and inhibited SIRT1, resulting in the dissociation of the SIRT1-p53 complex and stimulating p53 acetylation and p53-dependent cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATR | up-regulates activity
phosphorylation
|
CCAR2 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267662 |
Thr454 |
AAEAAPPtQEAQGET |
Homo sapiens |
|
| pmid |
sentence |
| 22735644 |
Here, we report that, in human cell lines, DNA damage triggered the phosphorylation of DBC1 on Thr454 by ATM (ataxia telangiectasia-mutated) and ATR (ataxia telangiectasia and Rad3-related) kinases. Phosphorylated DBC1 bound to and inhibited SIRT1, resulting in the dissociation of the SIRT1-p53 complex and stimulating p53 acetylation and p53-dependent cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A2 | up-regulates activity
phosphorylation
|
CCAR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267667 |
Thr454 |
AAEAAPPtQEAQGET |
Homo sapiens |
|
| pmid |
sentence |
| 24962073 |
CK2alphawas bound to DBC1 and phosphorylated DBC1. The phosphorylation of DBC1 by CK2alphawas evidenced by co-immunoprecipitation of CK2alphaand DBC1 in a GST pull-down assay, an in vitro kinase assay, and immunofluorescence staining. |In our results, CK2alpha affected the|These results suggest that DBC1 may be involved in the progression of gastric carcinoma by inducing the EMT and that it is closely associated with CK2alpha-mediated phosphorylation of DBC1. phosphorylation of Thr454 on DBC1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
CCAR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267666 |
Thr454 |
AAEAAPPtQEAQGET |
Homo sapiens |
|
| pmid |
sentence |
| 24962073 |
CK2alphawas bound to DBC1 and phosphorylated DBC1. The phosphorylation of DBC1 by CK2alphawas evidenced by co-immunoprecipitation of CK2alphaand DBC1 in a GST pull-down assay, an in vitro kinase assay, and immunofluorescence staining. |In our results, CK2alpha affected the|These results suggest that DBC1 may be involved in the progression of gastric carcinoma by inducing the EMT and that it is closely associated with CK2alpha-mediated phosphorylation of DBC1. phosphorylation of Thr454 on DBC1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCAR2 | down-regulates activity 
binding
|
HDAC3 |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267665 |
|
|
|
|
| pmid |
sentence |
| 26158765 |
Besides SIRT1, CCAR2 inhibits the activity of the histone-modifying enzymes SUV39H1 and HDAC3 [9, 10], thus playing an important role in chromatin structure regulation. |
|
| Publications: |
1 |
| + |
CCAR2 | down-regulates activity
binding
|
SUV39H1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267664 |
|
|
|
|
| pmid |
sentence |
| 26158765 |
Besides SIRT1, CCAR2 inhibits the activity of the histone-modifying enzymes SUV39H1 and HDAC3 [9, 10], thus playing an important role in chromatin structure regulation. |
|
| Publications: |
1 |
| + |
CCAR2 | down-regulates activity
binding
|
SIRT1 |
0.735 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22735644 |
Here, we report that, in human cell lines, DNA damage triggered the phosphorylation of DBC1 on Thr454 by ATM (ataxia telangiectasia-mutated) and ATR (ataxia telangiectasia and Rad3-related) kinases. Phosphorylated DBC1 bound to and inhibited SIRT1, resulting in the dissociation of the SIRT1-p53 complex and stimulating p53 acetylation and p53-dependent cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCAR2
- 
- 