4.0
Summary
| Name |  ZNRF1View Modifications |
| Full Name | E3 ubiquitin-protein ligase ZNRF1 |
| Synonyms | Nerve injury-induced gene 283 protein, RING-type E3 ubiquitin transferase ZNRF1, Zinc/RING finger protein 1 | NIN283 |
| Primary ID | Q8ND25 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ZNRF1 | down-regulates quantity by destabilization 
polyubiquitination
|
CAV1 | 0.365 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EGFR | up-regulates activity 
phosphorylation
|
ZNRF1 | 0.27 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
ZNRF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |