| Name
|
 UBA3
|
| Full Name |
NEDD8-activating enzyme E1 catalytic subunit |
| Synonyms |
NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3 | UBE1C |
| Primary ID |
Q8TBC4 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. |
4.0
binding