Summary

Name NEK9
Full Name Serine/threonine-protein kinase Nek9
Synonyms Nercc1 kinase, Never in mitosis A-related kinase 9, NimA-related protein kinase 9, NimA-related kinase 8, Nek8 | KIAA1995, NEK8, NERCC
Primary ID Q8TD19
Links - -
Type protein
Relations 4
Function Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation NEK7 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NEK6 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NEK9
Publications: 2 Organism: Homo Sapiens