4.0
Summary
| Name |  RNF138View Modifications |
| Full Name | E3 ubiquitin-protein ligase RNF138 |
| Synonyms | Nemo-like kinase-associated RING finger protein, NLK-associated RING finger protein, hNARF, RING finger protein 138, RING-type E3 ubiquitin transferase RNF138 | NARF |
| Primary ID | Q8WVD3 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ) |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
RNF138 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK2 | up-regulates activity
phosphorylation
|
RNF138 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates activity
phosphorylation
|
RNF138 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
RNF138 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF138 | down-regulates quantity by destabilization 
ubiquitination
|
RAD51D | 0.389 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UBE2K | up-regulates activity
binding
|
RNF138 | 0.537 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF138 | down-regulates quantity by destabilization
polyubiquitination
|
TCF7L2 | 0.324 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF138 | down-regulates quantity by destabilization
polyubiquitination
|
LEF1 | 0.305 |
| Publications: | 1 | Organism: | Homo Sapiens | |