3.0
Summary
| Name |  ARAP3
|
| Full Name | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 |
| Synonyms | Centaurin-delta-3, Cnt-d3 | CENTD3 |
| Primary ID | Q8WWN8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. |
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gtpase-activating protein