Relation Results

Summary

Name ARAP3
Full Name Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Synonyms Centaurin-delta-3, Cnt-d3 | CENTD3
Primary ID Q8WWN8
Links - -
Type protein
Relations 2
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO fa ...
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Type: Score: Layout: SPV 
0.5170.466ARAP3CDC42RAC1

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Relations
Regulator
Mechanism
target
score ℹ
+ ARAP3down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.517
Identifier Residue Sequence Organism Cell Line
SIGNOR-260457 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
+ ARAP3down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.466
Identifier Residue Sequence Organism Cell Line
SIGNOR-260456 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
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