| + |
CTTNBP2 | up-regulates activity 
binding
|
SHANK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269702 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 35562389 |
Synaptopathy, a key feature of autism spectrum disorders (ASD), is likely relevant to the impaired phase separation and/or transition of ASD-linked synaptic proteins. Here, we report that LLPS and zinc-induced liquid-to-gel phase transition regulate the synaptic distribution and protein-protein interaction of cortactin-binding protein 2 (CTTNBP2), an ASD-linked protein. CTTNBP2 forms self-assembled condensates through its C-terminal intrinsically disordered region and facilitates SHANK3 co-condensation at dendritic spines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTTNBP2 | up-regulates activity
binding
|
CTTN |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269703 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 22262902 |
Fluorescence recovery after photobleaching further suggested that CTTNBP2 modulates the mobility of cortactin in neurons. CTTNBP2 may thus help to immobilize cortactin in dendritic spines and control the density of dendritic spines. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
CTTNBP2
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- 