| + |
PRKD1 | down-regulates 
phosphorylation
|
CTTN |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164756 |
Ser298 |
EKLAKHEsQQDYSKG |
Homo sapiens |
|
| pmid |
sentence |
| 20363754 |
Pkd phosphorylates cortactin in vitro and in vivo at serine 298 thereby generating a 14-3-3 binding motif. In vitro, a phosphorylation-deficient cortactin-s298a protein accelerated vca-arp-cortactin-mediated synergistic actin polymerization and showed reduced f-actin binding |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182502 |
Ser348 |
EAVTSKTsNIRANFE |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19038333 |
Here we have investigated the possible role of pkd as a cortactin kinase. Using a mass spectrometric approach, we found that pkd phosphorylates cortactin on ser 298 examination of cortactin phosphorylation kinetics revealed that ser 298 serves as a priming site for subsequent phosphorylation of ser 348 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PAK1 | up-regulates 
phosphorylation
|
CTTN |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165216 |
Ser405 |
KTQTPPVsPAPQPTE |
Homo sapiens |
|
| pmid |
sentence |
| 20444238 |
Strikingly, we find that pak1 phosphorylation of cortactin on serine residues 405 and 418 increases its association with n-wasp. Thus, pak1, by controlling the interaction between cortactin and n-wasp, could regulate the polymerization of actin during clathrin-independent endocytosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169690 |
Ser405 |
KTQTPPVsPAPQPTE |
Homo sapiens |
|
| pmid |
sentence |
| 21079800 |
Strikingly, we find that pak1 phosphorylation of cortactin on serine residues 405 and 418 increases its association with n-wasp. Thus, pak1, by controlling the interaction between cortactin and n-wasp, could regulate the polymerization of actin during clathrin-independent endocytosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169694 |
Ser418 |
TEERLPSsPVYEDAA |
Homo sapiens |
|
| pmid |
sentence |
| 21079800 |
Strikingly, we find that pak1 phosphorylation of cortactin on serine residues 405 and 418 increases its association with n-wasp. Thus, pak1, by controlling the interaction between cortactin and n-wasp, could regulate the polymerization of actin during clathrin-independent endocytosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165220 |
Ser418 |
TEERLPSsPVYEDAA |
Homo sapiens |
|
| pmid |
sentence |
| 20444238 |
Strikingly, we find that pak1 phosphorylation of cortactin on serine residues 405 and 418 increases its association with n-wasp. Thus, pak1, by controlling the interaction between cortactin and n-wasp, could regulate the polymerization of actin during clathrin-independent endocytosis. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
MAPK3 | up-regulates
phosphorylation
|
CTTN |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169682 |
Ser405 |
KTQTPPVsPAPQPTE |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21079800 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165208 |
Ser405 |
KTQTPPVsPAPQPTE |
Homo sapiens |
|
| pmid |
sentence |
| 20444238 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165212 |
Ser418 |
TEERLPSsPVYEDAA |
Homo sapiens |
|
| pmid |
sentence |
| 20444238 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169686 |
Ser418 |
TEERLPSsPVYEDAA |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21079800 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PRKCD | up-regulates activity
phosphorylation
|
CTTN |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260889 |
Ser405 |
KTQTPPVsPAPQPTE |
Cricetulus griseus |
|
| pmid |
sentence |
| 26490115 |
Together these findings demonstrate that phosphorylation of cortactin on S405 and S418 residues is required for its interaction with WAVE2 in MCP1-induced cytoskeleton remodeling, facilitating HASMC migration. In addition, the MCP1-induced cortactin phosphorylation is dependent on PLCβ3-mediated PKCδ activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260890 |
Ser418 |
KTQTPPVsPAPQPTE |
Cricetulus griseus |
|
| pmid |
sentence |
| 26490115 |
Together these findings demonstrate that phosphorylation of cortactin on S405 and S418 residues is required for its interaction with WAVE2 in MCP1-induced cytoskeleton remodeling, facilitating HASMC migration. In addition, the MCP1-induced cortactin phosp |
|
| Publications: |
2 |
Organism: |
Cricetulus Griseus |
| + |
MAPK1 | up-regulates
phosphorylation
|
CTTN |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165200 |
Ser405 |
KTQTPPVsPAPQPTE |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20444238 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169674 |
Ser405 |
KTQTPPVsPAPQPTE |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21079800 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165204 |
Ser418 |
TEERLPSsPVYEDAA |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20444238 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169678 |
Ser418 |
TEERLPSsPVYEDAA |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21079800 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates activity
phosphorylation
|
CTTN |
0.795 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246513 |
Tyr421 |
RLPSSPVyEDAASFK |
in vitro |
|
| pmid |
sentence |
| 15169891 |
Erk phosphorylation and a mimicking S405,418D double mutation enhanced cortactin binding and activation of N-WASP. In contrast, Src phosphorylation inhibited the ability of cortactin previously phosphorylated by Erk, and that of S405,418D double mutant cortactin, to bind and activate N-WASP. Furthermore, Y-->D mutation of three tyrosine residues targeted by Src (Y421, Y466, and Y482) inhibited the ability of S405,418D cortactin to activate N-WASP. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SRC | down-regulates
phosphorylation
|
CTTN |
0.795 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98712 |
Tyr446 |
GTEPEPVySMEAADY |
Homo sapiens |
|
| pmid |
sentence |
| 12601080 |
Cortactin was first identified as a substrate of v-src (46) that mediates in vitro phosphorylation of residues tyr-421, tyr-466, and tyr-482 at the c terminus of the murine ortholog (47). Phosphorylation of these residues attenuates the f-actin cross-linking activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98716 |
Tyr470 |
AYATEAVyESAEAPG |
Homo sapiens |
|
| pmid |
sentence |
| 12601080 |
Cortactin was first identified as a substrate of v-src (46) that mediates in vitro phosphorylation of residues tyr-421, tyr-466, and tyr-482 at the c terminus of the murine ortholog (47). Phosphorylation of these residues attenuates the f-actin cross-linking activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98720 |
Tyr486 |
YPAEDSTyDEYENDL |
Homo sapiens |
|
| pmid |
sentence |
| 12601080 |
Cortactin was first identified as a substrate of v-src (46) that mediates in vitro phosphorylation of residues tyr-421, tyr-466, and tyr-482 at the c terminus of the murine ortholog (47). Phosphorylation of these residues attenuates the f-actin cross-linking activity |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
FGFR1 | down-regulates
phosphorylation
|
CTTN |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98618 |
Tyr446 |
GTEPEPVySMEAADY |
Homo sapiens |
|
| pmid |
sentence |
| 12601080 |
Cortactin, which is an actin-binding protein that also plays a role in actin cytoskeleton dynamics (45), was phosphorylated on tyr-446 in our assay (by fgfr1).Phosphorylation of these residues attenuates the f-actin cross-linking activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | up-regulates activity
dephosphorylation
|
CTTN |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248432 |
Tyr446 |
GTEPEPVySMEAADY |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 18387954 |
Here, we have identified cortactin, a central regulator of actin cytoskeletal dynamics, as a substrate of PTP1B. A trapping mutant of PTP1B binds cortactin at the phosphorylation site Tyr446, |Cortactin exerts its effects on the actin cytoskeleton by interacting directly with the Arp2/3 complex , F-actin |Src phosphorylates murine cortactin predominantly at three key sites in vitro, Tyr421, Tyr466, and Tyr482 (corresponding to Tyr421, Tyr470, and Try486 in human cortactin), resulting in decreased actin cross-linking activity |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
PTPRG | down-regulates activity
dephosphorylation
|
CTTN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254696 |
Tyr470 |
AYATEAVyESAEAPG |
in vitro |
|
| pmid |
sentence |
| 25624455 |
PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and VCL correlates with tyrosine dephosphorylation. In contrast, SRC inhibition correlates with hyperphosphorylation of the inhibitory Tyr530 residue and with dephosphorylation of the activatory Tyr419. Moreover, CDK2 and CTTN inhibition correlates with a hyperphosphorylation of the inhibitory Tyr15 and Tyr470, respectively. In contrast, a subgroup of 13 proteins, including BLNK, DOK2, ERBB2, GRIN2B, INSR, PDGFRA, PRKCD, PXN, STAT1, STAT2, STAT3, STAT5A, and ZAP70, appears to be activated by PTPRG activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CTTN | up-regulates 
|
Dendritic_spine_morphogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266595 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14684878 |
Cortactin is an F-actin binding protein and activator of the Arp2/3 actin nucleation machinery that also interacts with the postsynaptic density (PSD) protein Shank. Cortactin is concentrated in dendritic spines of cultured hippocampal neurons, and the N-terminal half of the protein containing the Arp2/3 and F-actin binding domains is necessary and sufficient for spine targeting. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA receptor_2D | up-regulates quantity
relocalization
|
CTTN |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266602 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 14684878 |
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTTNBP2 | up-regulates activity
binding
|
CTTN |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269703 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 22262902 |
Fluorescence recovery after photobleaching further suggested that CTTNBP2 modulates the mobility of cortactin in neurons. CTTNBP2 may thus help to immobilize cortactin in dendritic spines and control the density of dendritic spines. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
Gbeta | up-regulates
phosphorylation
|
CTTN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270051 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20444238 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA | up-regulates quantity
relocalization
|
CTTN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266598 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 14684878 |
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA receptor_2C | up-regulates quantity
relocalization
|
CTTN |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266601 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 14684878 |
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA receptor_2B | up-regulates quantity
relocalization
|
CTTN |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266600 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 14684878 |
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DIP2A | up-regulates activity
acetylation
|
CTTN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266589 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 31600191 |
DIP2A binds to cortactin and modulates cortactin acetylation. Autism candidate gene disconnected-interacting protein homolog 2 A (DIP2A) is known to be involved in acetylated coenzyme A (Ac-CoA) synthesis and is primarily expressed in the brain regions with abundant pyramidal neurons. We further identified that DIP2A interacted with cortactin, an activity-dependent spine remodeling protein. The binding activity of DIP2A-PXXP motifs (P, proline; X, any residue) with the cortactin-Src homology 3 (SH3) domain was critical for maintaining the level of acetylated cortactin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CTTNBP2NL | up-regulates activity
binding
|
CTTN |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261695 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23015759 |
CTTNBP2NL interacts with cortactin and targets cortactin to stress fibers. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
NMDA receptor_2A | up-regulates quantity
relocalization
|
CTTN |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266599 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 14684878 |
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTTN | up-regulates
|
Actin_cytoskeleton_reorganization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261696 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23015759 |
Through alternative splicing, a single CTTNBP2 gene encodes three different transcripts, namely short (S), long (L), and intron forms. The interaction with cortactin is required for the function of CTTNBP2-S in dendritic spine formation because the CTTNBP2-S mutant, which no longer interacts with cortactin, is unable to rescue the spine defects resulting from CTTNBP2 knockdown. Thus CTTNBP2-S may control cortactin–F-actin cytoskeletons and regulate the formation and maintenance of dendritic spines in neurons. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ERK1/2 | up-regulates
phosphorylation
|
CTTN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270164 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20444238 |
Cortactin is regulated by multiple phosphorylation events, including phosphorylation of s405 and s418 by extracellular regulated kinases (erk)1/2. Erk1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the arp2/3 regulator neuronal wiskott-aldrich syndrome protein (n-wasp), promoting actin polymerization and enhancing tumor cell movement. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
CTTN | up-regulates activity
binding
|
ARP2/3 |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11231575 |
Cortactin binds directly to the Arp2/3 complex and activates it to promote nucleation of actin filaments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
3.0
CTTN
- 
- 