| + |
PHF3 | down-regulates activity 
binding
|
RNA Polymerase II |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266964 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34667177 |
PHF3 interacts with RNA polymerase II through the SPOC domain. PHF3 negatively regulates mRNA levels. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. Our data suggest that PHF3 acts as a prominent effector of neuronal gene regulation by bridging transcription with mRNA decay. PHF3 SPOC preferentially binds RNA Pol II CTD phosphorylated on Serine-2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF3 | down-regulates activity
binding
|
POLR2A |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266965 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34667177 |
PHF3 interacts with RNA polymerase II through the SPOC domain. PHF3 negatively regulates mRNA levels. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. Our data suggest that PHF3 acts as a prominent effector of neuronal gene regulation by bridging transcription with mRNA decay. PHF3 SPOC preferentially binds RNA Pol II CTD phosphorylated on Serine-2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PHF3
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