4.0
Summary
| Name |  RDH5
|
| Full Name | Retinol dehydrogenase 5 |
| Synonyms | 11-cis RDH, 11-cis RoDH, 9-cis retinol dehydrogenase, 9cRDH, Retinol dehydrogenase 5, Short chain dehydrogenase/reductase family 9C member 5 | HSD17B9, RDH1, SDR9C5 |
| Primary ID | Q92781 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Pathways | Retinoic Acid Metabolism |
| Function | Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:11675386, PubMed:10588954, PubMed:9931293, PubMed:9115228). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:9931293, PubMed:29541409). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RDH5 | down-regulates quantity 
chemical modification
|
retinol | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Retinoic Acid Metabolism | |||
| + | RDH5 | up-regulates quantity 
chemical modification
|
retinal | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Retinoic Acid Metabolism | |||