| + |
KAT2A | down-regulates activity 
acetylation
|
H3Y2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269598 |
Lys10 |
RTKQTARkATAWQAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269596 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269604 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3-3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269595 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269603 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3C15 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269601 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269609 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269594 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269602 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3-2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269599 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269607 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3Y1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269597 |
Lys10 |
RTKQTARkATAWQAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3-5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269600 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269608 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CyclinD/CDK4 | up-regulates activity 
phosphorylation
|
KAT2A |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275496 |
Ser372 |
EEIYGANsPIWESGF |
|
|
| pmid |
sentence |
| 24870244 |
Activated cyclin D1-Cdk4 kinase phosphorylates and activates GCN5|GCN5 T272A/S372A (AA) phosphorylation by cyclin D1-CDK4 kinase is diminished compared to GCN5 wild-type (WT) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275497 |
Thr272 |
LNYWKLEtPAQFRQR |
|
|
| pmid |
sentence |
| 24870244 |
Activated cyclin D1-Cdk4 kinase phosphorylates and activates GCN5|GCN5 T272A/S372A (AA) phosphorylation by cyclin D1-CDK4 kinase is diminished compared to GCN5 wild-type (WT) |
|
| Publications: |
2 |
| + |
CDK4 | up-regulates activity
phosphorylation
|
KAT2A |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275494 |
Ser372 |
EEIYGANsPIWESGF |
|
|
| pmid |
sentence |
| 24870244 |
Activated cyclin D1-Cdk4 kinase phosphorylates and activates GCN5|GCN5 T272A/S372A (AA) phosphorylation by cyclin D1-CDK4 kinase is diminished compared to GCN5 wild-type (WT) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275495 |
Thr272 |
LNYWKLEtPAQFRQR |
|
|
| pmid |
sentence |
| 24870244 |
Activated cyclin D1-Cdk4 kinase phosphorylates and activates GCN5|GCN5 T272A/S372A (AA) phosphorylation by cyclin D1-CDK4 kinase is diminished compared to GCN5 wild-type (WT) |
|
| Publications: |
2 |
| + |
KAT2A | up-regulates
binding
|
SMAD3 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123318 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15009097 |
Gcn5 functions like pcaf, in that it binds to tgf-beta-specific r-smads, and enhances transcriptional activity induced by tgf-beta. In addition, gcn5, but not pcaf, interacts with r-smads for bone morphogenetic protein (bmp) signalling pathways, and enhances bmp-induced transcriptional activity, suggesting that gcn5 and pcaf have distinct physiological functions in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2A | up-regulates quantity 
|
SLC44A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260408 |
|
|
Homo sapiens |
VA13-TS4 Cell |
| pmid |
sentence |
| 21367571 |
Among these, SLC44A2 (a putative choline transporter) was strikingly upregulated by ethanol (three fold), and GCN5 silencing downregulated it |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269593 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2A | up-regulates
binding
|
SMAD2 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123315 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15009097 |
Gcn5 functions like pcaf, in that it binds to tgf-beta-specific r-smads, and enhances transcriptional activity induced by tgf-beta. In addition, gcn5, but not pcaf, interacts with r-smads for bone morphogenetic protein (bmp) signalling pathways, and enhances bmp-induced transcriptional activity, suggesting that gcn5 and pcaf have distinct physiological functions in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2A | form complex 
binding
|
SAGA complex |
0.723 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
Here we present the cryogenic-electron microscopy (cryo-EM) structure of human SAGA (hSAGA)|Human SAGA is a 20-subunit, 1.4-MDa complex with five functional modules (Fig. (Fig.1a):1a): a scaffolding core that includes TBP-associated factors (TAFs); a TRRAP (Transformation/Transcription domain Associated Protein) containing a phosphoinositide-3-kinase (PI3K)-related pseudoprotein kinase (ΨPIKK); a histone acetyltransferase (HAT); a deubiquitinase (DUB) and a metazoan-specific splicing (SPL) module |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
PLCG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275498 |
|
|
|
|
| pmid |
sentence |
| 24870244 |
The histone acetyltransferase GCN5 (general control non-repressed protein 5) acetylates PGC-1alpha and suppresses its transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1alpha. |
|
| Publications: |
1 |
3.0
KAT2A
- 
- 