Summary

Name CDK4
Full Name Cyclin-dependent kinase 4
Synonyms Cell division protein kinase 4, PSK-J3
Primary ID P11802
Links - -
Type protein
Relations 63
Pathways Pancreatic ductal adenocarcinoma (PDA)
Inhibitors 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide; R547; palbociclib; N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide; alvocidib; alvocidib hydrochloride
Function Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation SMAD3 0.747
Publications: 2 Organism: In Vitro
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/direct_inhibition.png phosphorylation RASSF1 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.747
Publications: 2 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.747
Publications: 4 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.926
Publications: 5 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates activity img/direct-activation.png phosphorylation TOB2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CELF1 0.414
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation RUNX3 0.414
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KAT2A 0.368
Publications: 2
+ up-regulates img/direct-activation.png phosphorylation FOXM1 0.607
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PELP1 0.363
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRCA1 0.649
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RBL1 0.8
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK4 0.557
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK4 0.563
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRDX1 0.228
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK4 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDK4 0.694
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2D 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK4 0.874
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 2 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDK4 0.288
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ down-regulates img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK4 0.938
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CDK4 0.964
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MYOD1 0.531
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK4 0.865
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDK4 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png binding CDK4 0.902
Publications: 2 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png , binding MEF2C 0.288
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2A 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDK4 0.593
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MYOG 0.338
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK4 0.8
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinD/CDK4 0.964
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)