Summary

Name CUL5
Full Name Cullin-5
Synonyms CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1 | VACM1
Primary ID Q93034
Links - -
Type protein
Relations 7
Function Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CUL5 0.327
Publications: 1 Organism: Chlorocebus Aethiops
+ form complex img/form-complex.png binding Elongin E3-Cul-5 0.929
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding CUL5 0.51
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by stabilization img/direct-activation.png binding CUL5 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png neddylation CUL5 0.62
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARIH2 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DAB1 0.333
Publications: 1 Organism: Chlorocebus Aethiops