Name	MOAP1
Full Name	Modulator of apoptosis 1
Synonyms	MAP-1, MAP1, Paraneoplastic antigen Ma4 \| PNMA4
Primary ID	Q96BY2
Links	- -
Type	protein
Relations	4
Function	Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525). Required for death receptor-dependent apoptosis (PubMed:11060313). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215). {ECO:0000250\|UniProtKB:Q9ERH6, ECO:0000269\|PubMed:11060313, ECO:0000269\|PubMed:15949439, ECO:0000269\|PubMed:16199525, ECO:0000269\|PubMed:33393215, ECO:0000269\|PubMed:33783314}.