4.0
Summary
| Name |  HES6View Modifications |
| Full Name | Transcription cofactor HES-6 |
| Synonyms | C-HAIRY1, Class B basic helix-loop-helix protein 41, bHLHb41, Hairy and enhancer of split 6 | BHLHB41 |
| Primary ID | Q96HZ4 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates activity 
phosphorylation
|
HES6 | 0.498 |
| Publications: | 1 | Organism: | In Vitro | |
| + | HES6 | up-regulates quantity by expression 
transcriptional regulation
|
E2F1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATOH1 | up-regulates quantity by expression
transcriptional regulation
|
HES6 | 0.441 |
| Publications: | 1 | Organism: | Homo Sapiens | |