| + |
LRFN5 | up-regulates activity 
binding
|
PTPRS |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27225731 |
SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development. we identified LAR-RPTPs as novel ligands of SALM5 that mediates SALM5-dependent presynaptic differentiation in a splicing-dependent manner. Our data indicate that SALM5 interacts with all three known LAR-RPTPs—LAR, PTPδ, and PTPσ (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRFN5 | up-regulates 
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264098 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
This study finds that all SALMs (SALMs 1–5) possess the abilityto promote neurite outgrowth and branching, as demonstrated byoverexpression and knockdown experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRFN5 | up-regulates
|
Synaptic_plasticity |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264085 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 27225731 |
These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264093 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 21736948 |
The SALM (synaptic adhesion-like molecule) family of adhesion molecules, also known as Lrfn, belongs to the superfamily of leucine-rich repeat (LRR)-containing adhesion molecules. Proteins of the SALM family, which includes five known members (SALMs 1-5), have been implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation.SALM3 and SALM5, but not other SALMs, possess synaptogenic activity, inducing presynaptic differentiation in contacting axons. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LRFN5 | up-regulates activity
binding
|
PTPRD |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264086 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 27225731 |
SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development. we identified LAR-RPTPs as novel ligands of SALM5 that mediates SALM5-dependent presynaptic differentiation in a splicing-dependent manner. Our data indicate that SALM5 interacts with all three known LAR-RPTPs—LAR, PTPδ, and PTPσ (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRFN5 | up-regulates activity
binding
|
PTPRF |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264087 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 27225731 |
SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development. we identified LAR-RPTPs as novel ligands of SALM5 that mediates SALM5-dependent presynaptic differentiation in a splicing-dependent manner. Our data indicate that SALM5 interacts with all three known LAR-RPTPs—LAR, PTPδ, and PTPσ (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LRFN5
- 
- 