Relation Results

Summary

Name SMG1
Full Name Serine/threonine-protein kinase SMG1
Synonyms SMG-1, hSMG-1, 61E3.4, Lambda/iota protein kinase C-interacting protein, Lambda-interacting protein | ATX, KIAA0421, LIP
Primary ID Q96Q15
Links - -
Type protein
Relations 4
Function Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence ...
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Type: Score: Layout: SPV 
0.9710.414SMG1UPF1TP53

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SMG1up-regulates img/direct-activation.png phosphorylation UPF1 0.971
Identifier Residue Sequence Organism Cell Line
SIGNOR-200785 Ser1089 GLSQPELsQDSYLGD Homo sapiens
pmid sentence
Smg-1 directly phosphorylates upf1 helicase, another key component of nmd, upon recognition of ptc on postspliced mrna during the initial round of translation. Phosphorylated-upf1 recruits the smg-5/smg-7 complex to induce ribosome dissociation and decapping-mediated decay. T28 and s1096 are responsible for phospho-specific recruitment of smg-6 to the n-terminal conserved region, and the smg-5/smg-7 heterodimer complex to the c-terminal sq-rich region of upf1, respectively
Identifier Residue Sequence Organism Cell Line
SIGNOR-200789 Ser1107 SQIDVALsQDSTYQG Homo sapiens
pmid sentence
Smg-1 directly phosphorylates upf1 helicase, another key component of nmd, upon recognition of ptc on postspliced mrna during the initial round of translation. Phosphorylated-upf1 recruits the smg-5/smg-7 complex to induce ribosome dissociation and decapping-mediated decay. T28 and s1096 are responsible for phospho-specific recruitment of smg-6 to the n-terminal conserved region, and the smg-5/smg-7 heterodimer complex to the c-terminal sq-rich region of upf1, respectively
Identifier Residue Sequence Organism Cell Line
SIGNOR-200793 Thr28 AELLGADtQGSEFEF Homo sapiens
pmid sentence
Smg-1 directly phosphorylates upf1 helicase, another key component of nmd, upon recognition of ptc on postspliced mrna during the initial round of translation. Phosphorylated-upf1 recruits the smg-5/smg-7 complex to induce ribosome dissociation and decapping-mediated decay. T28 and s1096 are responsible for phospho-specific recruitment of smg-6 to the n-terminal conserved region, and the smg-5/smg-7 heterodimer complex to the c-terminal sq-rich region of upf1, respectively
Publications: 3 Organism: Homo Sapiens
+ SMG1up-regulates img/direct-activation.png phosphorylation TP53 0.414
Identifier Residue Sequence Organism Cell Line
SIGNOR-125135 Ser15 PSVEPPLsQETFSDL Homo sapiens
pmid sentence
Hsmg-1 is a stress-activated kinase that phosphorylates p53 and hupf1 in vitrothe observation that hsmg-1 exhibits p53 (ser-15) kinase activity in vitro suggested that this pikk might be involved in genotoxic stress-induced p53 phosphorylation and stabilization in intact cells.
Publications: 1 Organism: Homo Sapiens
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