+ |
CSNK1D | up-regulates
phosphorylation
|
UHRF1 |
0.248 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-200349 |
Ser95 |
SELSDTDsGCCLGQS |
Homo sapiens |
|
pmid |
sentence |
23297342 |
We further show that uhrf1 physically interacts with _-trcp1 in a manner dependent on phosphorylation of serine 108 (s108(uhrf1)) within the dsg degron. Furthermore, we demonstrate that s108(uhrf1) phosphorylation is catalyzed by casein kinase 1 delta (ck1_) and is important for the recognition of uhrf1 by scf(_-trcp). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
Noncanonical PRC1 | down-regulates quantity by repression
transcriptional regulation
|
UHRF1 |
0.273 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252250 |
|
|
Mus musculus |
3T3-L1 Cell |
pmid |
sentence |
25533466 |
We concluded that FBXL10 recruits the noncanonical PRC1 complex to directly repress Cdk1, Uhrf1, and Pparg that may account for the FBXL10-mediated inhibition of adipogenesis. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
UHRF1 | down-regulates quantity by repression
transcriptional regulation
|
ABCB1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254224 |
|
|
Homo sapiens |
MCF-7/adr Cell |
pmid |
sentence |
20037778 |
we find UHRF1 plays an important role in inhibiting MDR1 promoter activity by directly binding to the MDR1 promoter. Overexpression of UHRF1 in NCI/ADR-RES cells can induce deacetylation of histones H3 and H4 on the MDR1 promoter, which is facilitated by recruitment of HDAC1 to the MDR1 promoter. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
Ub:E2 | up-regulates activity
ubiquitination
|
UHRF1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271020 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KDM2B | down-regulates quantity by repression
transcriptional regulation
|
UHRF1 |
0.29 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252245 |
|
|
Mus musculus |
3T3-L1 Cell |
pmid |
sentence |
25533466 |
We concluded that FBXL10 recruits the noncanonical PRC1 complex to directly repress Cdk1, Uhrf1, and Pparg that may account for the FBXL10-mediated inhibition of adipogenesis. |
|
Publications: |
1 |
Organism: |
Mus Musculus |