3.0
Summary
| Name |  CYTH2View Modifications |
| Full Name | Cytohesin-2 |
| Synonyms | ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2 | ARNO, PSCD2, PSCD2L |
| Primary ID | Q99418 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCB | down-regulates activity 
phosphorylation
|
CYTH2 | 0.311 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCG | down-regulates activity
phosphorylation
|
CYTH2 | 0.338 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCA | down-regulates activity
phosphorylation
|
CYTH2 | 0.311 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CYTH2 | up-regulates 
|
Neurite_outgrowth | 0.7 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | CYTH2 | up-regulates activity 
guanine nucleotide exchange factor
|
ARF6 | 0.883 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |