| + |
NDN | up-regulates 
|
CDKN2A |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253383 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24392140 |
In HEK293A cells transfected with luciferase reporter constructs, necdin relieves Bmi1-dependent repression of p16 promoter activity, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NDN | down-regulates quantity by destabilization 
binding
|
PIAS1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253387 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24911587 |
Necdin bound to PIAS1 central domains that are highly conserved among PIAS family proteins and suppressed PIAS1-dependent sumoylation of the substrates STAT1 and PML (promyelocytic leukemia protein). Remarkably, necdin promoted degradation of PIAS1 via the ubiquitin-proteasome pathway. In transfected HEK293A cells, amino- and carboxyl-terminally truncated mutants of PIAS1 bound to necdin but failed to undergo necdin-dependent ubiquitination. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAO1 | up-regulates activity
|
NDN |
0.241 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253388 |
|
|
Homo sapiens |
U-87MG Cell |
| pmid |
sentence |
| 25012566 |
We subsequently analyzed whether Gαo modulates the cellular activities of Necdin. Notably, expression of Gαo significantly augmented Necdin-mediated cellular responses, such as proliferation and differentiation. Moreover, activation of type 1 cannabinoid receptor (CB1R), a Gi/oα-coupled receptor, augmented cell growth suppression, which was mediated by Gαo and Necdin in U87MG cells containing CB1R, Gαo, and Necdin as normal components. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMI1 | down-regulates 
|
NDN |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253386 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24392140 |
In HEK293A cells transfected with luciferase reporter constructs, necdin relieves Bmi1-dependent repression of p16 promoter activity, whereas Bmi1 counteracts necdin-mediated repression of E2F1-dependent Cdk1 promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NDN | down-regulates
|
BMI1 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253384 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24392140 |
In HEK293A cells transfected with luciferase reporter constructs, necdin relieves Bmi1-dependent repression of p16 promoter activity, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NDN | up-regulates quantity by expression 
transcriptional regulation
|
MYC |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253381 |
|
|
Mus musculus |
Kidney |
| pmid |
sentence |
| 24349431 |
Deletion mapping demonstrated that the C-terminus of cystin and both termini of necdin are required for their mutual interaction. Speculating that these two proteins may function to regulate gene expression, we developed a luciferase reporter assay and observed that necdin strongly activated the Myc P1 promoter, and cystin did so more modestly. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NDN | up-regulates activity
binding
|
EID1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237614 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 18557765 |
The Prader-Willi syndrome protein necdin interacts with the E1A-like inhibitor of differentiation EID-1 and promotes myoblast differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NDN | up-regulates quantity by stabilization
binding
|
PPARGC1A |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26971449 |
Necdin binds and stabilizes PGC-1α|Necdin strongly stabilizes PGC-1α by inhibiting its ubiquitin-dependent degradation. Forced expression of necdin enhances mitochondrial function in primary cortical neurons and human SH-SY5Y neuroblastoma cells to prevent mitochondrial respiratory chain inhibitor-induced degeneration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NDN | down-regulates activity
binding
|
E2F1 |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253382 |
|
|
Mus musculus |
Neocortex |
| pmid |
sentence |
| 24392139 |
Necdin interacts with E2F transcription factors and suppresses E2F1-dependent transcriptional activation of the cyclin-dependent kinase Cdk1 gene. Here we show that necdin serves as a suppressor of NPC proliferation in the embryonic neocortex. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
NDN
- 
- 