Summary

Name RAD9A
Full Name Cell cycle checkpoint control protein RAD9A
Synonyms hRAD9, DNA repair exonuclease rad9 homolog A
Primary ID Q99638
Links - -
Type protein
Relations 13
Function Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation RAD9A 0.32
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png phosphorylation RAD9A 0.26
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAD9A 0.87
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAD9A
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAD9A 0.18
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAD9A 0.87
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAD9A 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TOPBP1 0.90
Publications: 1 Organism: Homo Sapiens