3.0
Summary
| Name |  MAPKAP1View Modifications |
| Full Name | Target of rapamycin complex 2 subunit MAPKAP1 |
| Synonyms | TORC2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, Stress-activated map kinase-interacting protein 1, SAPK-interacting protein 1, mSIN1 | MIP1, SIN1 |
| Primary ID | Q9BPZ7 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT1 | up-regulates activity 
phosphorylation
|
MAPKAP1 | 0.702 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | RPS6KB1 | down-regulates activity 
phosphorylation
|
MAPKAP1 | 0.565 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIP3 | up-regulates activity
chemical activation
|
MAPKAP1 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPKAP1 | up-regulates activity
binding
|
PRKCE | 0.264 |
| Publications: | 1 | Organism: | Homo Sapiens | |