+ |
KATNB1 | down-regulates
|
Microtubule_polimerization |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267181 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
10751153 |
Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. In this paper we demonstrate that human p60 katanin and the C-terminal domain of human p80 katanin both bind microtubules in vitro. Association of these two proteins results in an increased microtubule affinity and increased microtubule-severing activity in vitro. Association of these subunits in transfected HeLa cells increases microtubule disassembly activity and targeting to spindle poles. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KATNB1 | up-regulates quantity by stabilization
binding
|
KATNA1 |
0.779 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267173 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
10751153 |
In its active ATP-bound state, KATNA1 forms hexameric rings capable of binding to and severing microtubule polymers. Typically, KATNA1 binding to KATNB1 enhances severing, likely due to KATNB1 increasing the stability of the KATNA1 hexamer |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KATNAL2 | up-regulates activity
binding
|
KATNB1 |
0.603 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267180 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
10751153 |
Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. In this paper we demonstrate that human p60 katanin and the C-terminal domain of human p80 katanin both bind microtubules in vitro. Association of these two proteins results in an increased microtubule affinity and increased microtubule-severing activity in vitro. Association of these subunits in transfected HeLa cells increases microtubule disassembly activity and targeting to spindle poles. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KATNA1 | up-regulates activity
binding
|
KATNB1 |
0.779 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267174 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
10751153 |
In its active ATP-bound state, KATNA1 forms hexameric rings capable of binding to and severing microtubule polymers. Typically, KATNA1 binding to KATNB1 enhances severing, likely due to KATNB1 increasing the stability of the KATNA1 hexamer |
|
Publications: |
1 |
Organism: |
Homo Sapiens |