| + |
KATNAL2 | down-regulates quantity by destabilization 
binding
|
TUBD1 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267175 |
|
|
Mus musculus |
Testis |
| pmid |
sentence |
| 29136647 |
Here we show that KATNAL2 is critical for numerous aspects of this developmental process, including the initiation of the axoneme from the basal body, suppression of the spermatid centriole duplication cycle, sperm nuclear sculpting via the manchette, the attachment of the acrosome to the nucleus and the tethering of elongated spermatids to Sertoli cells via the tubulobulbar complex and ultimately sperm release via spermiation. KATNAL2 does not sever microtubules composed of α- and β-tubulin but does interact with δ- and ε-tubulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KATNAL2 | down-regulates quantity by destabilization
binding
|
TUBE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267176 |
|
|
Mus musculus |
Testis |
| pmid |
sentence |
| 29136647 |
KATNAL2 does not sever microtubules composed of α- and β-tubulin but does interact with δ- and ε-tubulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KATNAL2 | up-regulates activity 
binding
|
KATNB1 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267180 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10751153 |
Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. In this paper we demonstrate that human p60 katanin and the C-terminal domain of human p80 katanin both bind microtubules in vitro. Association of these two proteins results in an increased microtubule affinity and increased microtubule-severing activity in vitro. Association of these subunits in transfected HeLa cells increases microtubule disassembly activity and targeting to spindle poles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KATNAL2 | up-regulates 
|
Acrosome_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267179 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28347630 |
The majority of elongated spermatids also displayed a detached acrosome (Fig 5B), indicating that KATNAL2, or KATNAL2-regulated structures, have a role in the deposition of ‘adhesive components’ into the acroplaxome. The acroplaxome is an electron dense structure that overlies the anterior pole of the sperm nucleus and is thought to play a pivotal role in acrosome formation and attachment. These data strongly suggest that KATNAL2 is required for multiple aspects of male haploid germ cell development, and depending on the cellular context, KATNAL2 may act in either a KATNB1-dependent (manchette function) and KATNB1-independent manner (acrosome and axoneme development). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KATNAL2
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