Summary

Name CTDSP1
Full Name Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1 | NIF3, NLIIF, SCP1
Primary ID Q9GZU7
Links - -
Type protein
Relations 38
Function Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation POLR2A
Publications: 24 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD1
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SMAD3
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TWIST1 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD1 0.43
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding NLI/Lmx1.1/Isl1
Publications: 1 Organism: Homo Sapiens