Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277564 |
Tyr54 |
PMIGDKVyVHYKGKL |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
34077419 |
SRMS binds FKBP51 and phosphorylates tyrosine 54. Under nutrient-replete conditions, SRMS phosphorylates the PHLPP scaffold FK506-binding protein 51 (FKBP51), disrupts the FKBP51-PHLPP complex, and promotes FKBP51 degradation through the ubiquitin-proteasome pathway. |
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