| + |
MAP3K11 | up-regulates 
phosphorylation
|
MAP2K4 |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128420 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
|
| pmid |
sentence |
| 15328343 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75836 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
| pmid |
sentence |
| 10727406 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48574 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
COS-1 Cell |
| pmid |
sentence |
| 9003778 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251420 |
Ser257 |
ISGQLVDsIAKTRDA |
in vitro |
|
| pmid |
sentence |
| 9162092 |
Ser221 and, to a lesser extent, Thr225 in MKK4 as necessary sites for basal and MEKK-induced autophosphorylation and activation of MKK4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251421 |
Thr261 |
LVDSIAKtRDAGCRP |
in vitro |
|
| pmid |
sentence |
| 9162092 |
Ser221 and, to a lesser extent, Thr225 in MKK4 as necessary sites for basal and MEKK-induced autophosphorylation and activation of MKK4. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV ATTACHMENT AND ENTRY, TNF-alpha Signaling, TGF-beta Signaling |
| + |
AKT1 | down-regulates 
phosphorylation
|
MAP2K4 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236494 |
Ser80 |
IERLRTHsIESSGKL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11707464 |
Akt phosphorylated sek1 on serine 78. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
AKT | down-regulates
phosphorylation
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244285 |
Ser80 |
IERLRTHsIESSGKL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11707464 |
Akt phosphorylated sek1 on serine 78. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EGFR Signaling |
| + |
AKT | down-regulates activity
phosphorylation
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275980 |
Ser80 |
IERLRTHsIESSGKL |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 11707464 |
Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation. In vitro and in vivo (32)P labeling indicated that Akt phosphorylated SEK1 on serine 78. The SEK1 mutant SEK1(S78A) was resistant to Akt-induced inhibition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EGFR Signaling |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK13 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273956 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273955 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK14 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27973 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 7535770 |
Recently, two MAP kinase kinases (MKK3 and MKK4) that activate p38 MAP kinase have been identified. The mechanism of p38 activation is mediated by dual phosphorylation on Thr-180 and Tyr-182 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK8 |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244982 |
Thr183 |
AGTSFMMtPYVVTRY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9724739 |
MKK4/7, in turn, phosphorylates JNK on residues 183 and 185 (1720). Activated JNK phosphorylates its substrates, c-Jun, ATF2, ELK1, and p53 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251419 |
Tyr185 |
TSFMMTPyVVTRYYR |
in vitro |
|
| pmid |
sentence |
| 11062067 |
Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7. Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183) in three SAPK1/JNK1 isoforms tested (JNK1 alpha 1, JNK2 alpha 2 and JNK3 alpha 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249654 |
Tyr185 |
TSFMMTPyVVTRYYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9724739 |
MKK4/7, in turn, phosphorylates JNK on residues 183 and 185 (1720). Activated JNK phosphorylates its substrates, c-Jun, ATF2, ELK1, and p53 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, SAPK/JNK Signaling, SARS-CoV ATTACHMENT AND ENTRY, TNF-alpha Signaling |
| + |
MAP2K4 | up-regulates
phosphorylation
|
MAPK9 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260615 |
Thr183 |
ACTNFMMtPYVVTRY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17761173 |
We next examined whether the phosphorylation of JNK at threonine 183 (Thr183) and tyrosine 185 (Tyr185) was enhanced by GRASP‐1 expression. Phosphorylation of Thr183 and Tyr185 by SEK1/MKK4, which is in turn phosphorylated and activated by several kinases including MEKK1, is known to activate JNK1/2/3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197998 |
Tyr185 |
TNFMMTPyVVTRYYR |
Homo sapiens |
|
| pmid |
sentence |
| 22730327 |
Mkk4, which activates p38gamma, p38delta, and jnk2 to phosphorylate p53 on ser-33 and cause a transient g(1) arrest. A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast, Prostate Gland |
| + |
MAP2K4 | up-regulates
phosphorylation
|
MAPK10 |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260614 |
Thr221 |
AGTSFMMtPYVVTRY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17761173 |
We next examined whether the phosphorylation of JNK at threonine 183 (Thr183) and tyrosine 185 (Tyr185) was enhanced by GRASP‐1 expression. Phosphorylation of Thr183 and Tyr185 by SEK1/MKK4, which is in turn phosphorylated and activated by several kinases including MEKK1, is known to activate JNK1/2/3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137605 |
Tyr223 |
TSFMMTPyVVTRYYR |
Homo sapiens |
|
| pmid |
sentence |
| 15911620 |
Two mapkks, sek1 and mkk7, synergistically activate jnk. Sek1 prefers the tyr-185 residue, and mkk7 prefers the thr-183 residue (17, 19). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75792 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10715136 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subs of map kinases, respectively. Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11242034 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subs of map kinases, respectively. Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45360 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8974401 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subgroups of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subgroups of map kinases, respectively. here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83721 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) and p38 subs of map kinases, respectively. Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
MAP3K1 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236380 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
| pmid |
sentence |
| 9712898 |
The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, sek1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9712898 |
The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, SEK1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TNF-alpha Signaling |
| + |
MAP3K5 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45373 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
| pmid |
sentence |
| 8974401 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45366 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK10 |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251423 |
Tyr223 |
TSFMMTPyVVTRYYR |
in vitro |
|
| pmid |
sentence |
| 10715136 |
Activation of JNK3 alpha 1 requires both MKK4 and MKK7. both MKK4 and MKK7 were required for bisphosphorylation and maximal enzyme activity. a processive mechanism for JNK3R1 activation that requires phosphorylation of Thr 221 by MKK7 prior to phosphorylation of Tyr 223 by MKK4 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAP2K4 | down-regulates
phosphorylation
|
RXRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80619 |
Tyr249 |
VEPKTETyVEANMGL |
Homo sapiens |
|
| pmid |
sentence |
| 10938283 |
Phosphorylation by mkk4/sek1 had profound effects on the biochemical properties of rxr, inhibiting the expression of genes activated by rxr-retinoic acid receptor complexes. Tyr-249 in the rxr de region was required for the inhibitory effect of mkk4/sek1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K4 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62369 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9841871 |
When truncated mapkkk4 (deltamapkkk4) was overexpressed in hek293 cells, it was constitutively activeco-expressed map kinase kinase (mkk)-1, mkk-4, mkk-3 and mkk-6 were activated in vivo by deltamapkkk4. All of the above mkks purified from escherichia coli were phosphorylated and activated by deltamapkkk4 immunoprecipitates in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
JNK |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83729 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260759 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 21561061 |
Activation of JNK pathway components in 3b-expressing cells was assessed by analyzing levels of active phosphorylated formsof JNK and its upstream kinase MEK4. An enhanced phosphor-ylation of JNK and MEK4 was observed in cells expressing 3b ascompared to control cells expressing GFP |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236110 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |
| + |
3b | up-regulates activity 
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260761 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21561061 |
An enhanced phosphorylation of JNK and MEK4 was observed in cells expressing 3b ascompared to control cells expressing GFP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, SARS-CoV ATTACHMENT AND ENTRY |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
p38 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260722 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
FLNA | up-regulates
binding
|
MAP2K4 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45887 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 9006895 |
Sek-1 binds directly and specifically to the actin-binding protein abp-280. As a consequence, active sek-1 is capable of phosphorylating and activating in vitro added bacterial recombinant sapk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| + |
SH3RF1 | up-regulates
binding
|
MAP2K4 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96952 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12514131 |
We confirmed that posh binds activated rac1 and find that it also binds all mlk family members tested and interacts with mkk4/7 as well as jnk1 and jnk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
TAOK2 | up-regulates activity
binding
|
MAP2K4 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74864 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 10660600 |
Immunoprecipitated psk phosphorylates myelin basic protein and transfected psk stimulates mkk4 and mkk7 and activates the c-jun n-terminal kinase mitogen-activated protein kinase pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAP3K20 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243348 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11416147 |
We show here that members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are expressed in neuronal cells and are likely to act between Rac1/Cdc42 and MKK4 and -7 in death signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K8 | up-regulates
phosphorylation
|
MAP2K4 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22435554 |
Furthermore, we found that immunoprecipitated tpl-2 could directly phosphorylate and activate both mek-1 and mkk4 (also known as sek-1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-50618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9278437 |
Mitogen-activated protein kinase kinase 4 (mkk4)/stress-activated protein kinase/extracellular signal-regulated kinase (sek1), a dual-specificity kinase that phosphorylates and activates jnk, synergized with tak1 in activating jnk.Taken together, these results identify TAK1 as a regulator in the HPK1 --> TAK1 --> MKK4/SEK1 --> JNK kinase cascade and indicate the involvement of JNK in the TGF-beta signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |
| + |
MAP3K3 | up-regulates activity
binding
|
MAP2K4 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48628 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 9162092 |
These data indicate that mkk3 is preferentially activated by mekk3, whereas mkk4 is activated both by mekk2 and mekk3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EPHB1 | up-regulates activity
relocalization
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275922 |
|
|
|
|
| pmid |
sentence |
| 26319181 |
The phosphorylated CNK1 interacts with ephrinB1. The binding of ephrinB1 to CNK1 connects RhoA and p115RhoGEF with ephrinB1-associated MKK4, promoting JNK activation and cell migration. |
|
| Publications: |
1 |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP2K4 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10523642 |
Overexpression of full-length jsap1 in cos-7 cells led to a considerable enhancement of jnk3 activation, and modest enhancement of jnk1 and jnk2 activation, by the mekk1-sek1 pathwaythe regions of jsap1 that bound jnk, sek1, and mekk1 were distinct from one another. Jnk and mekk1 also bound jsap1 in vitro, suggesting that these interactions are direct. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLNA | up-regulates activity
binding
|
MAP2K4 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260629 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20156194 |
We used Filamin-A-deficient cells to show that Filamin A enhances MKK7 activation and is important for synergistic stress-induced JNK activation in vivo. Thus Filamin A is a novel member of the group of scaffold proteins whose function is to link two MAPKKs together and promote JNK activation. The present study provides evidence that Filamin A is one of the ‘binder’ molecules presumed to directly and closely connect MKK4 and MKK7 so that they can mediate this tyrosine/threonine phosphorylation. We showed that Filamin A (as well as Filamin B and C) associate with MKK7 and MKK4, but not with JNK1 itself |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| + |
MAP3K2 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107695 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11343802 |
Both mekk2 and mekk3 are able to activate the jun kinase pathway in vivo. However, following routine immunoprecipitation in triton x-100, mekk2 but not mekk3 is able to effectively phosphorylate both sek-1 and mek-1 and to undergo autophosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WDR62 | up-regulates activity
relocalization
|
MAP2K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271715 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 30566428 |
In the WT brain, the WDR62 scaffold organizes a protein complex including MEKK3, MKK4/7, and JNK1 to control NPC development during corticogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
MAP2K4
- 
- 