4.0
Summary
| Name |  HIPK3View Modifications |
| Full Name | Homeodomain-interacting protein kinase 3 |
| Synonyms | Androgen receptor-interacting nuclear protein kinase, ANPK, Fas-interacting serine/threonine-protein kinase, FIST, Homolog of protein kinase YAK1 | DYRK6, FIST3, PKY |
| Primary ID | Q9H422 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation |
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