Summary

Name SFXN1
Full Name Sideroflexin-1
Synonyms SFXN1_HUMAN |
Primary ID Q9H9B4
Links - -
Type protein
Relations 1
Pathways One-carbon Metabolism
Function Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). Transports both D-serine and L-serine (PubMed:30442778). Also able to transport other amino-acids, such as alanine (PubMed:30442778). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png relocalization L-serine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:One-carbon Metabolism