| + |
ZBTB20 | down-regulates quantity by repression 
transcriptional regulation
|
NFKBIA |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266868 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23776228 |
ChIP and next generation high-throughput DNA sequencing assay showed that ZBTB20 specifically bound to IκBα gene promoter (+1 to +60 region) after TLR activation. ZBTB20 could inhibit IκBα gene transcription, govern IκBα protein expression, and then promote NF-κB activation. Therefore, transcriptional repressor ZBTB20 is needed to promote full activation of TLR signaling and TLR-triggered innate immune response by selectively suppressing the suppressor IκBα gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZBTB20 | down-regulates quantity by repression
transcriptional regulation
|
AFP |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266867 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23776228 |
Zinc finger and BTB domain-containing 20 (ZBTB20), a member of BTB/POZ family, functions in neurogenesis and represses α-fetoprotein gene transcription in liver. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZBTB20 | up-regulates 
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266866 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29748916 |
The transcription factor (TF) Zbtb20 is important for the hippocampal specification and the regulation of neurogenesis of neocortical projection neurons. Herein, we show a critical involvement of the TF Zbtb20 in the neurogenesis of both projection neurons and interneurons of the olfactory bulb during embryonic stages |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
ZBTB20
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