| + |
MECP2 | up-regulates 
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264966 |
|
|
Mus musculus |
Neural Stem Cell |
| pmid |
sentence |
| 19427855 |
Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264967 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25420914 |
Our current study highlights the phosphorylation, but not the overall expression level, of MeCP2 as a significant regulatory mechanism in regulating adult neurogenesis in the hippocampus. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Hippocampus |
| Pathways: | Rett syndrome |
| + |
ASCL1 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265174 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 24243019 |
Here we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1|Accordingly, Ascl1-mutant mice show severe defects in neurogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Retinoic acid Signaling |
| + |
NOTCH1 | down-regulates 
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265769 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9601631 |
Signalling through activated Notch is known both to control multiple cell fate determinations (in both invertebrates and vertebrates) and to inhibit developmental processes, such as neurogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Retinoic acid Signaling, Rett syndrome |
| + |
DLX5 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265797 |
|
|
in vitro |
|
| pmid |
sentence |
| 19195802 |
DLX5 and adjacent DLX6 are homeobox genes working in neurogenesis. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Rett syndrome |
| + |
EGFL7 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20372059 |
EGFL7 drives the formation of neurons from neural stem cells. In the embryonic and adult brain this process is essential for neurogenesis and homeostasis of the nervous system. In this review, we discuss the implications of our findings for adult neurogenesis and illustrate the potential of EGFL7 to serve as an agent to increase neurogenesis and the self-renewal potential of the brain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEUROG1 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265172 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 18400164 |
While the mechanisms by which Ngn2 promotes neurogenesis have been characterized, little is known about how Ngn2 confers neuronal cell-type identity during spinal cord development. Ngn1 and Ngn2, two mammalian orthologs of the Drosophila proneural bHLH gene atonal, are expressed in overlapping patterns throughout the developing nervous system and act as important regulators of developmental neurogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Retinoic acid Signaling |
| + |
GAP43 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266771 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 26865625 |
Growth-associated protein 43 (GAP43), a protein kinase C (PKC)-activated phosphoprotein, is often implicated in axonal plasticity and regeneration. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ADNP | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266758 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12888219 |
Mouse ADNP was shown to be expressed at the time of neural tube closure, detected at E7.5 and increased on E9.5. Expression was augmented in the brain (E12.5), sustained throughout embryogenesis and regulated by VIP. In conclusion, ADNP is identified here as a new key gene essential for organogenesis in the developing embryo and may be implicated as a clinical target associated with proper neurodevelopment. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TERF2 | down-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266805 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 27117401 |
During neuronal differentiation, use of an alternative splice site on the rat telomere repeat-binding factor 2 (TRF2) mRNA generates a short TRF2 protein isoform (TRF2-S) capable of derepressing neuronal genes. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MEF2C | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265800 |
|
|
in vitro |
|
| pmid |
sentence |
| 23001426 |
In brain, MEF2C is essential for early neurogenesis, neuronal migration, and differentiation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Rett syndrome |
| + |
NEUROG2 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265173 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 18400164 |
While the mechanisms by which Ngn2 promotes neurogenesis have been characterized, little is known about how Ngn2 confers neuronal cell-type identity during spinal cord development. Ngn1 and Ngn2, two mammalian orthologs of the Drosophila proneural bHLH gene atonal, are expressed in overlapping patterns throughout the developing nervous system and act as important regulators of developmental neurogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Retinoic acid Signaling |
| + |
ZBTB20 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266866 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29748916 |
The transcription factor (TF) Zbtb20 is important for the hippocampal specification and the regulation of neurogenesis of neocortical projection neurons. Herein, we show a critical involvement of the TF Zbtb20 in the neurogenesis of both projection neurons and interneurons of the olfactory bulb during embryonic stages |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ERK1/2 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264978 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 12676795 |
Activation of the Ras-MAPK/Erk signaling cascade is essential for neurotrophin-promoted differentiation of neurons and PC12 cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Oxytocin signaling, Rett syndrome |
| + |
MTOR | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265771 |
|
|
|
|
| pmid |
sentence |
| 29789464 |
The mTOR complexes are essential to neurogenesis and the establishment of neural circuits. | Activation of mTOR complexes exerts profound effects on all the processes of neurogenesis, including dendrite formation. |
|
| Publications: |
1 |
| Pathways: | Rett syndrome |
3.0
Neurogenesis