+ |
AMPK | up-regulates activity
phosphorylation
|
ACSS2 |
0.277 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271823 |
Ser659 |
PGLPKTRsGKIMRRV |
|
|
pmid |
sentence |
28820290 |
This translocation is mediated by AMP-activated protein kinase (AMPK)-dependent ACSS2 Ser659 phosphorylation and subsequent exposure of the nuclear localization signal of ACSS2 to KPNA1/importin α5 for binding. In the nucleus, ACSS2 forms a complex with TFEB (transcription factor EB) and utilizes the acetate generated from histone deacetylation to locally produce acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes. |
|
Publications: |
1 |
+ |
PRKAA1 | up-regulates activity
phosphorylation
|
ACSS2 |
0.281 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271822 |
Ser659 |
PGLPKTRsGKIMRRV |
|
|
pmid |
sentence |
28820290 |
This translocation is mediated by AMP-activated protein kinase (AMPK)-dependent ACSS2 Ser659 phosphorylation and subsequent exposure of the nuclear localization signal of ACSS2 to KPNA1/importin α5 for binding. In the nucleus, ACSS2 forms a complex with TFEB (transcription factor EB) and utilizes the acetate generated from histone deacetylation to locally produce acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes. |
|
Publications: |
1 |
+ |
ACSS2 | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271826 |
|
|
|
|
pmid |
sentence |
10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
Publications: |
1 |
+ |
ACSS2 | down-regulates quantity
chemical modification
|
acetate |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271827 |
|
|
|
|
pmid |
sentence |
10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
Publications: |
1 |
+ |
ACSS2 | down-regulates quantity
chemical modification
|
coenzyme A(4-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271828 |
|
|
|
|
pmid |
sentence |
10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
Publications: |
1 |