| + |
TLR9 | up-regulates activity 
binding
|
TICAM2 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266750 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RNF216 | down-regulates quantity by destabilization 
ubiquitination
|
TLR9 |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271505 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15107846 |
Here we describe how a RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and proteolytic degradation of some TLRs. Triad3A overexpression promoted substantial degradation of TLR4 and TLR9 with a concomitant decrease in signaling, but did not affect TLR2 expression or signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BGLF5 | down-regulates quantity by destabilization
post transcriptional regulation
|
TLR9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266633 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21191071 |
The EBV lytic-phase protein BGLF5 reduces TLR9 expression through mRNA degradation. We established that the EBV early protein BGLF5 degrades TLR9 mRNA in vitro, providing a mechanism for its contribution to TLR9 downregulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
LMP1 | down-regulates quantity by repression 
transcriptional regulation
|
TLR9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266804 |
|
|
Homo sapiens |
RPMI-8226 Cell |
| pmid |
sentence |
| 20980631 |
We determined that the EBV oncoprotein latent membrane protein 1 (LMP1) is a strong inhibitor of TLR9 transcription. These data show that the oncoprotein LMP1 downregulates TLR9 promoter activity in B cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
TLR9 | up-regulates activity
binding
|
TIRAP |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266748 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
TLR9 | up-regulates activity
binding
|
TICAM1 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266749 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
TLR9 | up-regulates activity
binding
|
MYD88 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266742 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
3.0
TLR9
- 
- 