+ |
FBXO8 | up-regulates activity
binding
|
Cullin 1-RBX1-Skp1 |
0.387 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271765 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
18094045 |
Fbx8 Is a Component of the SCF Complex and Mediates Ubiquitination of Arf6. We first examined whether Fbx8 makes a complex with Cul1, through its binding to Skp1. We expressed GST-tagged Fbx8 together with FLAG-tagged Skp1 and Myc-tagged Cul1 in Cos-7 cells and found that Myc-Cul1 is coprecipitated with GST-Fbx8 in the presence of FLAG-Skp1 (Figure 1A). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272307 |
|
|
Homo sapiens |
SW-620 Cell |
pmid |
sentence |
31024008 |
Here, we show that loss of FBX8 accelerates chemical-induced colon tumorigenesis. FBX8 directly targets GSTP1 for ubiquitin-mediated proteasome degradation in CRC. |
|
Publications: |
2 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
+ |
FBXO8 | down-regulates quantity by destabilization
binding
|
GSTP1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272304 |
|
|
Homo sapiens |
SW-620 Cell |
pmid |
sentence |
31024008 |
Here, we show that loss of FBX8 accelerates chemical-induced colon tumorigenesis. FBX8 directly targets GSTP1 for ubiquitin-mediated proteasome degradation in CRC. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FBXO8 | down-regulates quantity by destabilization
binding
|
ARF6 |
0.699 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271764 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
18094045 |
Fbx8 Is a Component of the SCF Complex and Mediates Ubiquitination of Arf6. We first examined whether Fbx8 makes a complex with Cul1, through its binding to Skp1. We expressed GST-tagged Fbx8 together with FLAG-tagged Skp1 and Myc-tagged Cul1 in Cos-7 cells and found that Myc-Cul1 is coprecipitated with GST-Fbx8 in the presence of FLAG-Skp1 (Figure 1A). |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |