4.0
Summary
| Name |  MAP3K20View Modifications |
| Full Name | Mitogen-activated protein kinase kinase kinase 20 |
| Synonyms | Human cervical cancer suppressor gene 4 protein, HCCS-4, Leucine zipper- and sterile alpha motif-containing kinase, MLK-like mitogen-activated protein triple kinase, Mixed lineage kinase-related kinase, MLK-related kinase, MRK, Sterile alpha motif- and leucine zipper-containing kinase AZK | MLTK |
| Primary ID | Q9NYL2 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP3K20 | up-regulates 
phosphorylation
|
MAP3K20 | 0.2 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | MAP3K20 | up-regulates activity
phosphorylation
|
MAP2K7 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MAP3K20 | down-regulates activity 
phosphorylation
|
ARHGDIB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K20 | up-regulates activity
phosphorylation
|
MAP2K4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKN1 | up-regulates
phosphorylation
|
MAP3K20 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |