Summary

Name CALCOCO1
Full Name Calcium-binding and coiled-coil domain-containing protein 1
Synonyms Calphoglin, Coiled-coil coactivator protein, Sarcoma antigen NY-SAR-3 | KIAA1536
Primary ID Q9P1Z2
Links - -
Type protein
Relations 1
Function Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

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Relations

Regulator Mechanism target score ℹ
+ SMURF1 img/unknown.png ubiquitination CALCOCO1 0.2
Publications: 1 Organism: In Vitro