4.0
Summary
| Name |  UVRAGView Modifications |
| Full Name | UV radiation resistance-associated gene protein |
| Synonyms | p63 |
| Primary ID | Q9P2Y5 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Pathways | Autophagy |
| Function | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SMURF1 | down-regulates activity 
ubiquitination
|
UVRAG | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MTOR | up-regulates activity 
phosphorylation
|
UVRAG | 0.41 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | UVRAG | up-regulates activity
binding
|
RINT1 | 0.499 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UVRAG | up-regulates activity
binding
|
BECN1 | 0.861 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Autophagy | |||
| + | UVRAG | up-regulates activity
binding
|
PIK3C3 | 0.81 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Autophagy | |||
| + | UVRAG | form complex 
binding
|
Vps34 Complex II | 0.822 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Autophagy | |||
| + | TFE3 | up-regulates quantity by expression 
transcriptional regulation
|
UVRAG | 0.265 |
| Publications: | 1 | |||
| + | ZRANB1 | up-regulates activity
deubiquitination
|
UVRAG | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |