| + |
DNMT3B | down-regulates quantity by repression 
transcriptional regulation
|
GSTM2 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271687 |
|
|
|
|
| pmid |
sentence |
| 21246532 |
Knockdown of Sp1 in normal lung cells reduced GST-M2 expression, and silencing of DNMT-3b increased GST-M2 expression in lung cancer cells. |
|
| Publications: |
1 |
| + |
DNMT3B | down-regulates quantity by repression
transcriptional regulation
|
IL32 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254127 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 20889550 |
A virus or dsRNA in human PBMCs from healthy volunteers. We demonstrate that the NF-κB and CREB pathways play key roles in the activation of IL-32 production in response to influenza virus infection in A549 human lung epithelial cells.|Overexpression assays combined with RNA interference show that DNA methyltransferases DNMT1 and DNMT3b are critical for IL32 promoter methylation and gene silencing before viral infection. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT3B | down-regulates quantity by repression 
transcriptional regulation
|
DPP6 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268964 |
|
|
Mus musculus |
P-19 Cell |
| pmid |
sentence |
| 23409053 |
In the absence of Dnmt3b, Dnmt3a was associated with Dpp6 gene promoter and regulated its expression and methylation in P19 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268963 |
|
|
|
|
| pmid |
sentence |
| 23409053 |
Dnmt3b was responsible for transcriptional silencing of Dpp6 gene as depletion of Dnmt3b resulted in increased mRNA and protein expression of Dpp6. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, |
| + |
DNMT3B | up-regulates quantity by expression 
transcriptional regulation
|
BAG3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254111 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18413740 |
In contrast, an increase in BAG-1, BAG-3, and BAG-4 gene expression was observed in HCT116 cells overexpressing either DNMT1 (DNMT1+) or DNMT3B (DNMT3B+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT3B | form complex 
binding
|
DNMT1/DNMT3B |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90845 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12145218 |
We show that the human de novo enzymes hdnmt3a and hdnmt3b form complexes with the major maintenance enzyme hdnmt1 /in vivo co-expression of hdnmt1 and hdnmt3a or hdnmt3b leads to methylation spreading in the genome, suggesting co-operation between de novo and maintenance enzymes during dna methylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT3B | up-regulates quantity by expression
transcriptional regulation
|
BAG4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254113 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18413740 |
In contrast, an increase in BAG-1, BAG-3, and BAG-4 gene expression was observed in HCT116 cells overexpressing either DNMT1 (DNMT1+) or DNMT3B (DNMT3B+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT3B | down-regulates quantity by repression
transcriptional regulation
|
HOXB13 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254145 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 22808286 |
EZH2 recruited DNMT3b to HOXB13 promoter to form a repression complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNMT3B | up-regulates quantity by expression
transcriptional regulation
|
BAG1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254109 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18413740 |
DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-29b | down-regulates quantity by repression
post transcriptional regulation
|
DNMT3B |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264544 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 26344767 |
We also found that miR-199a expression and blockade (see below for details) potentiated and attenuated, respectively, the phosphorylation levels in neurons of S6 ribosomal protein, which signify the activation of mTOR signaling, indicating that miR-199a positively regulates mTOR signaling activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
DNMT3B
- 
- 