3.0
Summary
| Name |  ZRANB1View Modifications |
| Full Name | Ubiquitin thioesterase ZRANB1 |
| Synonyms | EC 3.4.19.12, TRAF-binding domain-containing protein, hTrabid, Zinc finger Ran-binding domain-containing protein 1 | TRABID |
| Primary ID | Q9UGI0 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Required in the stress fiber dynamics and cell migration (PubMed:21834987). {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:33637724}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK1A1 | up-regulates activity 
phosphorylation
|
ZRANB1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates activity
phosphorylation
|
ZRANB1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ZRANB1 | up-regulates activity
deubiquitination
|
UVRAG | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZRANB1 | down-regulates activity 
deubiquitination
|
TWIST1 | 0.342 |
| Publications: | 1 | Organism: | Homo Sapiens | |